ELK Biotechnology FoxO3A rabbit pAb
FoxO3A 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA 등에 사용 가능. 인간 FKHRL1 유래 펩타이드로 면역화됨. 세포 내 위치 연구 및 apoptosis 관련 전사인자 분석에 적합. -20°C에서 1년 보관 가능.
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제품명
FoxO3A rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | FOXO3; FKHRL1; FOXO3A; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Other applications: Not yet tested |
| Immunogen | Synthesized peptide derived from human FKHRL1 (AA range: 220–269) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 90 kD |
| GeneID (Human) | 2309 |
| Human Swiss-Prot No | O43524 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Cytoplasm, cytosol, nucleus, mitochondrion matrix, mitochondrion outer membrane; peripheral membrane protein (cytoplasmic side).
Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, 15084260, 16751106).
Translocates to the nucleus upon oxidative stress and absence of survival factors (PubMed:10102273, 16751106).
Dephosphorylation in response to autophagy-inducing stimuli promotes nuclear translocation (By similarity).
AMPK-dependent translocation into mitochondria occurs under metabolic stress (PubMed:23283301, 29445193).
Serum deprivation increases nuclear localization, activating SOX9 expression and promoting chondrogenesis (By similarity).
배경 (Background)
This gene belongs to the forkhead family of transcription factors characterized by a distinct forkhead domain.
It likely functions as a trigger for apoptosis through expression of genes necessary for cell death.
Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
Alternatively spliced transcript variants encoding the same protein have been observed.
[provided by RefSeq, Jul 2008]
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