ELK Biotechnology Filamin 1 rabbit pAb
Filamin 1 rabbit polyclonal antibody로 인간, 마우스, 랫트 시료에서 FLNA 단백질 검출에 적합. WB, IHC, IF, ELISA 등 다양한 응용 가능. 인간 Filamin A 유래 합성 펩타이드로 면역화. 세포골격 및 세포 이동 연구에 유용.
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Filamin 1 rabbit pAb
제품 개요
Filamin 1 rabbit polyclonal antibody는 인간 Filamin A 단백질을 인식하며, 세포골격 구조 및 세포 이동 관련 연구에 적합합니다. 다양한 응용 분야(WB, IHC, IF, ELISA)에서 높은 특이성과 재현성을 제공합니다.
스펙 정보
| 항목 | 내용 |
|---|---|
| Product name | Filamin 1 rabbit pAb |
| Alternative Names | FLNA; FLN; FLN1; Filamin-A; FLN-A; Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human Filamin A (AA range: 2121–2170) |
| Host | Rabbit |
| Storage | −20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 280 kD |
| GeneID (Human) | 2316 |
| Human Swiss-Prot No. | P21333 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cytoplasm, cell cortex, cytoskeleton, perikaryon, growth cone. Colocalizes with CPMR1 and F-actin in DRG neuron growth cone (by similarity). |
Background
Filamin A (FLNA) is an actin-binding protein that crosslinks actin filaments and links them to membrane glycoproteins. It plays a crucial role in cytoskeletal remodeling, influencing cell shape and migration. FLNA interacts with integrins, transmembrane receptor complexes, and second messengers. Mutations in this gene are associated with several syndromes, including periventricular nodular heterotopia (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been identified.
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