ELK Biotechnology Fes rabbit pAb
Fes rabbit pAb는 인간 및 생쥐 FES 단백질을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 합성 펩타이드(AA 131-180)를 면역원으로 사용하며, 세포질 및 세포막에 주로 분포합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology Fes rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Fes rabbit pAb |
| Alternative Names | FES; FPS; Tyrosine-protein kinase Fes/Fps; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human FES (AA range: 131-180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kD |
| Gene ID (Human) | 2242 |
| Human Swiss-Prot No. | P07332 |
| Species Reactivity | Human; Mouse |
세포 내 위치 (Cellular Localization)
Cytoplasm, cytosol; cytoskeleton; cell membrane (peripheral membrane protein, cytoplasmic side); cytoplasmic vesicle; Golgi apparatus; cell junction, focal adhesion.
Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity.
Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR.
Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
Background
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities.
The gene product has tyrosine-specific protein kinase activity, which is required for maintenance of cellular transformation.
Its chromosomal location has been linked to a specific translocation event identified in patients with acute promyelocytic leukemia.
It is also involved in normal hematopoiesis and growth factor/cytokine receptor signaling.
Alternative splicing results in multiple variants encoding different isoforms.
(Provided by RefSeq, Jan 2009)
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