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ELK Biotechnology FEN-1 rabbit pAb
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ELK Biotechnology FEN-1 rabbit pAb

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FEN-1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트 시료에 반응. DNA 복구 및 복제 관련 연구에 적합. -20°C에서 1년 보관 가능.

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pk
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ELK Biotechnology ES2336-100UL FEN-1 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES2336-50UL FEN-1 rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원

ELK Biotechnology · ELK Biotechnology FEN-1 rabbit pAb

FEN-1 rabbit pAb

제품 정보

항목 내용
Product name FEN-1 rabbit pAb
Alternative Names FEN1; RAD2; Flap endonuclease 1; FEN-1; DNase IV; Flap structure-specific endonuclease 1; Maturation factor 1; MF1; hFEN-1
Applications WB; IHC; IF; ELISA
Recommended Dilutions WB: 1/500–1/2000
IHC: 1/100–1/300
IF: 1/200–1/1000
ELISA: 1/20000
Not yet tested in other applications
Immunogen Synthesized peptide derived from human FEN1 (AA range: 86–135)
Host Rabbit
Storage -20°C, 1 year
Clonality Polyclonal
Isotype IgG
Concentration 1 mg/ml
Observed Band 42 kD
Gene ID (Human) 2237
Human Swiss-Prot No. P39748
Cellular Localization [Isoform 1]: Nucleus, nucleolus, nucleoplasm (relocalizes upon DNA damage)
[Isoform FENMIT]: Mitochondrion
Species Reactivity Human; Mouse; Rat

Background

The protein encoded by this gene removes 5′ overhanging flaps in DNA repair and processes the 5′ ends of Okazaki fragments during lagging strand DNA synthesis. It interacts with AP endonuclease 1 during long-patch base excision repair, coordinating substrate transfer between enzymes. This protein belongs to the XPG/RAD2 endonuclease family and is essential for cell-free DNA replication. DNA secondary structures can inhibit flap processing at trinucleotide repeats, potentially leading to site-specific expansions.

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