ELK Biotechnology EphA2/3/4 rabbit pAb

제품명

EphA2/3/4 rabbit pAb

대체 명칭

EPHA2; ECK; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA3; ETK; ETK1; HEK; TYRO4; Ephrin type-A receptor 3; EPH-like kinase 4; EK4; hEK4; HEK; Human embryo kinase; Tyrosine-protein kinase TYRO

적용 분야

• Western Blot (WB)
• Immunofluorescence (IF)
• ELISA

권장 희석 배수

• Western Blot: 1/500 - 1/2000
• Immunofluorescence: 1/200 - 1/1000
• ELISA: 1/40000
• Other applications: Not yet tested

면역원 (Immunogen)

The antiserum was produced against synthesized peptide derived from human EPHA2/3/4.
Amino acid range: 556–605

보관 조건

-20°C에서 보관 (유효기간 1년)

항체 정보

세포 내 위치 (Cellular Localization)

• Cell membrane; Single-pass type I membrane protein
• Cell projection, ruffle membrane; Single-pass type I membrane protein
• Cell projection, lamellipodium membrane; Single-pass type I membrane protein
• Cell junction, focal adhesion
• Present at regions of cell-cell contacts and at the leading edge of migrating cells (PubMed:19573808, PubMed:20861311)
• Relocates from the plasma membrane to cytoplasmic and perinuclear regions in cancer cells (PubMed:18794797)

배경 (Background)

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors are involved in developmental processes, particularly in the nervous system. Members of this subfamily typically contain a single kinase domain and an extracellular region with a cysteine-rich domain and two fibronectin type III repeats. Ephrin receptors are divided into two groups based on extracellular domain sequence similarity and ligand affinity (ephrin-A or ephrin-B). This gene encodes a receptor binding ephrin-A ligands, and mutations are associated with certain genetically related cataract disorders. [RefSeq, May 2010]