ELK Biotechnology eIF4E rabbit pAb
eIF4E 단백질에 특이적인 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 유래 합성 펩타이드로 면역화되었으며, 세포질 및 핵 내에서 eIF4E 단백질 검출에 활용됩니다. 농도 1 mg/ml, -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology eIF4E rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | eIF4E rabbit pAb |
| Alternative Names | EIF4E; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human eIF4E. AA range: 168-217 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kD |
| Gene ID (Human) | 1977 |
| Human Swiss-Prot No | P06730 |
| Cellular Localization | Cytoplasm, P-body, Stress granule, Nucleus. Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:25923732). Imported into the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:10856257). |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5′ end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5′-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation are associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
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