ELK Biotechnology eIF3ε rabbit pAb

ELK Biotechnology eIF3ε rabbit pAb

제품 정보

Background

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi, and eIF-5 to form the 43S preinitiation complex (43S PIC). It stimulates mRNA recruitment to the 43S PIC and scanning for AUG recognition. The complex is also involved in disassembly and recycling of posttermination ribosomal complexes, preventing premature joining of 40S and 60S subunits.

• Mass spectrometry references: PubMed:17322308, PubMed:18599441
• Post-translational modification: Phosphorylated; phosphorylation enhanced upon serum stimulation
• Similarity: Belongs to the eIF-3 subunit F family; contains one MPN (JAB/Mov34) domain
• Subunit structure: Component of the eIF-3 complex composed of 13 subunits (EIF3A–EIF3M). The complex includes three stable modules:
  • Module A: EIF3A, EIF3B, EIF3G, EIF3I
  • Module B: EIF3F, EIF3H, EIF3M
  • Module C: EIF3C, EIF3D, EIF3E, EIF3K, EIF3L
    EIF3C binds EIF3B and EIF3H, linking the three modules. EIF3J is a labile subunit binding via EIF3B. The complex interacts with RPS6KB1 under nutrient depletion and participates in mitogenic stimulation via FRAP1–RAPTOR complex activation.