ELK Biotechnology eIF2α rabbit pAb
ELK Biotechnology의 eIF2α rabbit pAb는 인간, 마우스, 랫, 원숭이, 어류에 반응하는 폴리클로날 항체입니다. IF, WB, IHC, ELISA에 사용 가능하며, 합성 펩타이드 항원으로 제작되었습니다. 단백질 합성 개시 조절 연구에 적합한 고품질 항체입니다.
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제품명
eIF2α rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200 WB: 1:500–1:2000 IHC: 1:100–1:300 ELISA: 1:10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human eIF2 alpha (AA range: 21–70) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 38 kDa |
| GeneID (Human) | 1965 |
| Human Swiss-Prot No. | P05198 |
| Cellular Localization | Cytoplasm, Stress granule. Colocalizes with NANOS3 in the stress granules. |
| Species Reactivity | Human; Mouse; Rat; Monkey; Fish |
Background
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 consists of three nonidentical subunits: the 36 kDa EIF2-alpha (EIF2S1), the 38 kDa EIF2-beta (EIF2S2; MIM 603908), and the 52 kDa EIF2-gamma (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]). [Supplied by OMIM, Feb 2010]
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