ELK Biotechnology DRP1 rabbit pAb
DRP1 단백질을 인식하는 토끼 다클론 항체로, 인간·마우스·랫트 시료에 반응합니다. IF, WB, IHC, ELISA 등 다양한 응용에 적합하며, 미토콘드리아 및 퍼옥시좀 분열 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
DRP1 rabbit pAb
제품 개요
DRP1 단백질에 특이적인 토끼 폴리클로날 항체입니다. 미토콘드리아 및 퍼옥시좀의 분열 조절 연구에 적합하며, 다양한 응용 실험에서 사용 가능합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | DRP1 rabbit pAb |
| Alternative Names | DNM1L; DLP1; DRP1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-related protein 1 |
| Applications | IF, WB, IHC, ELISA |
| Recommended Dilutions | IF: 1:50–200 WB: 1:500–1:2000 IHC: 1:100–1:300 ELISA: 1:10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from DRP1 (AA range: 580–660) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kDa |
| Gene ID (Human) | 10059 |
| Human Swiss-Prot No. | O00429 |
| Species Reactivity | Human, Mouse, Rat |
세포 내 위치
Cytoplasm, cytosol, Golgi apparatus, endomembrane system; peripheral membrane protein.
Mitochondrion outer membrane; peroxisome; clathrin-coated pits; cytoplasmic vesicles including secretory and synaptic vesicle membranes.
Recruited to mitochondria during mitosis via RALA and RALBP1, and translocated through O-GlcNAcylation and interaction with FIS1.
Colocalized with MARCHF5 and MIEF1 at mitochondrial membranes; recruitment inhibited by C11orf65/MFI (By similarity).
Background
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer’s disease.
Mutations are associated with the autosomal dominant disorder encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF).
Alternative splicing results in multiple transcript variants encoding different isoforms.
[Provided by RefSeq, Jun 2013]
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