ELK Biotechnology Dbf4 rabbit pAb
Dbf4 단백질에 특이적인 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. DNA 복제 및 세포 증식 조절 연구에 적합하며, 인간, 마우스, 원숭이 시료 반응. -20°C에서 1년 보관 가능.
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제품명
Dbf4 rabbit pAb
제품 개요
Dbf4 단백질은 CDC7의 조절 서브유닛으로서 DNA 복제 및 세포 증식에 핵심적인 역할을 수행합니다. 본 항체는 인간 DBF4 유래 합성 펩타이드(AA 10-59)를 면역원으로 제작된 토끼 다클론 항체입니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | Dbf4 rabbit pAb |
| Alternative Names | DBF4; ASK; DBF4A; ZDBF1; Protein DBF4 homolog A; Activator of S phase kinase; Chiffon homolog A; DBF4-type zinc finger-containing protein 1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/10000 Other applications not yet tested |
| Immunogen | Synthesized peptide derived from human DBF4 (AA range: 10–59) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 77 kDa |
| Gene ID (Human) | 10926 |
| Human Swiss-Prot No | Q9UBU7 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Monkey |
Background
Function: Regulatory subunit for CDC7 that activates its kinase activity, playing a central role in DNA replication and cell proliferation. Required for S phase progression. The CDC7-DBF4A complex selectively phosphorylates the MCM2 subunit at Ser-40 and Ser-53, regulating initiation of DNA replication.
Induction: Expressed at low levels in G1 phase, increases during G1-S phase, and remains high through S and G2-M phases.
Post-translational Modification (PTM): Phosphorylated upon DNA damage, likely by ATM or ATR.
Similarity: Contains one DBF4-type zinc finger and two BRCT domains.
Subunit: Forms a complex with CDC7. CDC7 can form distinct complexes with DBF4A or DBF4B, both stable under replication stress. Interacts with MEN1, MCM2, ORC2L, ORC4L, and ORC6L.
Tissue Specificity: Highly expressed in testis and thymus; also expressed in most cancer cell lines.
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