ELK Biotechnology CYP1B1 rabbit pAb
CYP1B1 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 적합합니다. 인간, 랫드, 마우스에서 반응하며, 약물 대사 및 발암물질 대사 연구에 활용됩니다. 장기 보관은 -20°C에서 가능합니다.
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- ES2094-xxxxx (2개 옵션)
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제품명
CYP1B1 rabbit pAb
제품 개요
CYP1B1 단백질을 특이적으로 인식하는 토끼 폴리클로날 항체입니다. Cytochrome P450 계열 효소 연구 및 약물 대사 관련 실험에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CYP1B1 rabbit pAb |
| Alternative Names | CYP1B1; Cytochrome P450 1B1; CYPIB1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human CYP1B1 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| Gene ID (Human) | 1545 |
| Human Swiss-Prot No. | Q16678 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular Localization | Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane; Mitochondrion. Located primarily in endoplasmic reticulum. Upon treatment with TCDD, CYP1B1 is also targeted to mitochondria. |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17β-estradiol. Mutations in this gene have been associated with primary congenital glaucoma, suggesting that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
[provided by RefSeq, Jul 2008]
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