
ELK Biotechnology Cyclin E1 rabbit pAb
Cyclin E1 단백질을 인식하는 rabbit polyclonal 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 Cyclin E1 합성 펩타이드(AA 91-140)로 면역화. 세포 주기 G1/S 전이에 관련된 단백질 연구에 적합. -20°C에서 1년 보관 가능.
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Cyclin E1 rabbit pAb
제품 개요
Cyclin E1 단백질을 인식하는 rabbit polyclonal 항체입니다. Cyclin E1은 세포 주기 G1/S 전이에서 중요한 역할을 하는 단백질로, CDK2와 복합체를 형성하여 세포 분열 조절에 관여합니다. 본 항체는 인간 Cyclin E1의 합성 펩타이드(AA 91-140)를 면역원으로 제작되었습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cyclin E1 rabbit pAb |
| Alternative Names | CCNE1; CCNE; G1/S-specific cyclin-E1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Cyclin E1 (AA range: 91–140) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 49 kDa |
| Gene ID (Human) | 898 |
| Human Swiss-Prot No. | P24864 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat; Pig |
Background
The protein encoded by this gene belongs to the highly conserved cyclin family, characterized by a periodic fluctuation in protein abundance during the cell cycle. Cyclins act as regulators of CDK kinases. Cyclin E1 forms a complex with CDK2, essential for the G1/S transition. Overexpression of Cyclin E1 has been observed in various tumors, leading to chromosomal instability and potential tumorigenesis. It is also associated with the phosphorylation of NPAT protein, which participates in cell cycle regulation.
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