ELK Biotechnology COL1A2 rabbit pAb
COL1A2 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 쥐, 랫트 시료에 반응. 합성 펩타이드(AA 471-520)로 면역화. -20°C에서 1년 보관 가능. 세포외 기질 단백질 연구에 적합.
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제품명
COL1A2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | COL1A2; Collagen alpha-2(I) chain; Alpha-2 type I collagen |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Collagen I alpha2 (AA range: 471–520) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 125 kD |
| Gene ID (Human) | 1278 |
| Human Swiss-Prot No. | P08123 |
| Cellular Localization | Secreted, extracellular space, extracellular matrix |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes the pro-alpha2 chain of type I collagen, whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I collagen is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis, and tendon.
Mutations in this gene are associated with osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome.
Symptoms associated with mutations in this gene tend to be less severe than those in COL1A1, reflecting the different role of alpha2 chains in matrix integrity.
Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. (Provided by R. Dalgleish, Feb 2008)
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