ELK Biotechnology CCRL1 rabbit pAb
인간 및 생쥐 CCRL1 단백질을 인식하는 토끼 폴리클로날 항체. WB, IF, ELISA에 적합하며 다양한 희석 범위에서 사용 가능. 합성 펩타이드 면역원으로 제작되어 높은 특이성과 재현성을 제공. -20℃에서 1년 보관 가능.
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제품명
CCRL1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CCRL1; CCBP2; CCR11; VSHK1; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; CCRL1; CCX CKR |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CCRL1 (AA range: 291-340) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 40 kD |
| Gene ID (Human) | 51554 |
| Human Swiss-Prot No. | Q9NPB9 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Early endosome, Recycling endosome, Cell membrane (Multi-pass membrane protein).
Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor and is targeted to degradation, while the receptor is recycled back to the cell membrane.
배경 (Background)
The protein encoded by this gene is a member of the G protein-coupled receptor family and is a receptor for C-C type chemokines. This receptor binds dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK.
A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described.
[Provided by RefSeq, Jul 2013]
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