ELK Biotechnology COL1A2 rabbit pAb

제품 개요

제품명: COL1A2 rabbit pAb
공급업체: ELK Biotechnology

COL1A2 단백질은 Type I collagen의 알파2 사슬로, 결합조직 및 뼈, 각막, 진피, 건 등에서 풍부하게 존재합니다. 본 항체는 인간 Collagen I 유래 합성 펩타이드(AA 1-50)를 면역원으로 제작된 토끼 폴리클로날 항체입니다.

제품 사양

Background

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis, and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I–IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene tend to be less severe than those in COL1A1, reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
[Provided by R. Dalgleish, Feb 2008]