ELK Biotechnology Cofilin rabbit pAb
Cofilin rabbit pAb는 인간, 마우스, 랫트 시료에서 사용 가능한 다클론 항체입니다. Western blot, IF, ELISA에 적합하며 actin 세포골격 관련 연구에 활용됩니다. 합성 펩타이드 항원으로 제작되었으며 -20°C 보관 시 1년 안정합니다.
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Cofilin rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cofilin rabbit pAb |
| Alternative Names | CFL1; CFL; Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin; non-muscle isoform; CFL2; Cofilin-2; Cofilin, muscle isoform |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Cofilin (AA range: 61-110) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 19 kD |
| GeneID (Human) | 1073 / 1072 |
| Human Swiss-Prot No | P23528 / Q9Y281 |
| Species Reactivity | Human; Mouse; Rat |
Cellular Localization
Nucleus matrix, cytoplasm, cytoskeleton, cell projection (ruffle membrane, lamellipodium membrane, growth cone, axon).
Colocalizes with actin cytoskeleton in membrane ruffles and lamellipodia.
Detected at cleavage furrow and contractile ring during cytokinesis.
Almost completely localized in the nucleus under heat shock or 10% DMSO exposure.
Background
Cofilin 1 (CFL1) is a human protein that can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner.
Phosphorylation by LIM kinase promotes Rho-induced actin cytoskeleton reorganization.
Cofilin is widely distributed intracellularly, binds and depolymerizes filamentous F-actin, and inhibits monomeric G-actin polymerization.
It also participates in translocation of the actin–cofilin complex from cytoplasm to nucleus.
[Source: OMIM, Apr 2004]
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