Thermo Fisher Scientific PTPN2 Recombinant Rabbit Monoclonal Antibody (JE57-07)

Applications and Tested Dilution

Product Specifications

Target Information

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal splice variants with distinctly different subcellular localizations.
The shorter 45 kDa isoform is exclusively nuclear in resting cells but redistributes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kDa isoform is found in the endoplasmic reticulum and appears to have different physiological substrates from the smaller isoform.
Although found in many cell types and tissues, TC-PTP is particularly prominent in hematopoietic cells. Knockout mice lacking TC-PTP are viable at birth but die within 3–5 weeks due to erythropoietic and lymphopoietic deficits, indicating a critical role in bone marrow maturation. TC-PTP dephosphorylates a wide range of phosphoproteins, including p52 Shc and receptors for EGF, insulin, and growth hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.