Thermo Fisher Scientific SOS1 Recombinant Rabbit Monoclonal Antibody (JE30-06)
SOS1 단백질을 표적으로 하는 재조합 토끼 단클론 항체로, Western blot에 적합합니다. 인간, 생쥐, 랫트 반응성을 가지며 HEK293 세포에서 발현되었습니다. Protein A로 정제된 액상 형태로, 연구용으로 사용됩니다.
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Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE30-06 |
| Immunogen | Recombinant protein within human SOS1 aa 1–150/1,333 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931299 |
Target Information
Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region.
Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves activation of the MAPK cascade central to cellular proliferation, survival, and differentiation. Growth factor stimulation rapidly induces phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by MAP/ERK kinase disrupts the Grb2-Sos complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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