Thermo Fisher Scientific Ki-67 Monoclonal Antibody (4A1)
인간 Ki-67 단백질을 타깃으로 하는 Mouse monoclonal antibody로, 세포 증식 마커 연구에 사용됩니다. IHC, ICC/IF, ELISA 등 다양한 응용에 적합하며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA515525
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A1 |
| Immunogen | Synthetic peptide corresponding to aa (CEDLAGFKELFQTPG) of human KI67, conjugated to KLH (aa 1100–1113) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10980978 |
Product Specific Information
MA5-15525 targets Ki-67 in indirect ELISA and IHC applications, showing reactivity with human samples.
The immunogen is a synthetic peptide corresponding to aa (CEDLAGFKELFQTPG) of human Ki-67, conjugated to KLH.
MA5-15525 detects Ki-67, which has a predicted molecular weight of approximately 358 kDa.
Target Information
Ki-67 is a nuclear protein expressed during various stages of the cell cycle, particularly in late G1, S, G2, and M phases.
It associates with euchromatin at the perichromosomal layer, centromeric heterochromatin, and the nucleolus via its forkhead-associated (FHA) domain.
Ki-67 shows cell cycle–dependent localization: perinucleolar in G1, nuclear matrix in G2, and chromosomal during M phase.
It serves as a proliferation marker since it is absent in G0 cells but increases from G1 through mitosis.
Ki-67 antibodies are widely used to assess proliferative activity in neoplasms, correlating with tumor grade and prognosis.
Commonly used as a neuronal marker of cell cycling and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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