Thermo Fisher Scientific GPATCH3 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human GPATCH3. Recombinant protein control fragment (Product #RP-94564). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GPATCH3,uniProtId:Q96I76-1,ncbiNodeId:9606,antigenRange:62-163,antigenLength:525,antigenImageFileName:PA5-56918_GPATCH3_Q96I76-1_Rabbit.svg,antigenImageFileNamePDP:PA5-56918_GPATCH3_Q96I76-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642133

Product Specific Information

Immunogen sequence: PNSALIPTDP AAEGQLLSQT SATDVRPLST RDSTPIQTRT CCCVISVRGL AQAQRLIRMY SGRRWLDSHG TWLPGRCLIR RLRLPTEASG LGSFPFKTRK EL

Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 72%.

Target Information

GPATCH3 is a protein coding gene involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.