Thermo Fisher Scientific PDCD5 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total PDCD5.

Target Information

Programmed cell death 5 (PDCD5) is a human apoptosis-related protein involved in early and universal apoptosis processes. PDCD5 is widely expressed and upregulated in cells undergoing apoptosis, translocating rapidly from the cytoplasm to the nucleus. It has a compact core structure with two mobile N-terminal alpha-helices and a flexible unstructured C-terminal region. Charged residues are critical for apoptosis promotion and cellular translocation. PDCD5 facilitates apoptosis and enhances TAJ/TROY-induced paraptosis-like cell death. It interacts with Tip60 as a co-activator to promote apoptosis. Variations in the PDCD5 promoter region may influence susceptibility to certain cancers, including chronic myelogenous leukemia and lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.