
Thermo Fisher Scientific PDCD5 Polyclonal Antibody
PDCD5 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, 인간 및 생쥐 시료에 반응합니다. Western blot에 적합하며, 세포사멸 관련 연구용으로 사용됩니다. 액상 형태로 -20°C에서 보관하며, 친화 크로마토그래피로 정제되었습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PDCD5 (Accession O14737), corresponding to amino acid residues E94–Y125. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899405 |
Product Specific Information
This antibody detects endogenous levels of total PDCD5.
Target Information
Programmed cell death 5 (PDCD5) is a human apoptosis-related protein involved in early and universal apoptosis processes. PDCD5 is widely expressed and upregulated in cells undergoing apoptosis, translocating rapidly from the cytoplasm to the nucleus. It has a compact core structure with two mobile N-terminal alpha-helices and a flexible unstructured C-terminal region. Charged residues are critical for apoptosis promotion and cellular translocation. PDCD5 facilitates apoptosis and enhances TAJ/TROY-induced paraptosis-like cell death. It interacts with Tip60 as a co-activator to promote apoptosis. Variations in the PDCD5 promoter region may influence susceptibility to certain cancers, including chronic myelogenous leukemia and lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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