Thermo Fisher Scientific ZRANB2 Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
DEDEDDADLS KYNLDASEEE DSNKKKSNRR SRS

Target Information

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression.
ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1, or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family.
Localized to the nucleus, ZNF265 functions as a splicing factor responsible for alternatively splicing Tra-2 beta transcripts and is thought to interfere with constitutive 5′-splice selection.
ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity.
Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.