Thermo Fisher Scientific TAB1 Polyclonal Antibody
TAB1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 연구용으로 TGF-beta 관련 신호전달 연구에 적합.
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Thermo Fisher Scientific TAB1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–257 of Human TAB1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546076 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, A375, GL261, C8D30
- Predicted reactivity: Mouse (97%), Rat (95%), Pig (96%), Chicken (90%), Rhesus Monkey (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which mediates various intracellular signaling pathways such as those induced by TGF-beta, interleukin 1, and WNT-1. TAB1 interacts and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for TAK1 binding and activation, while the N-terminal portion may act as a dominant-negative inhibitor of TGF-beta. TAB1 can also activate MAPK14/p38alpha, representing an alternative activation pathway contributing to MAPK14 responses.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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