Thermo Fisher Scientific NR1H3 Monoclonal Antibody (OTI1F5), TrueMAB
NR1H3 단백질을 인식하는 마우스 단클론 항체로, Western blot에 최적화됨. Human 종에 반응하며, carrier-free 형태로 제공되어 결합 실험에 적합. 동결건조 상태로 보관하며, 재구성 후 1 mg/mL 농도로 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 69–329 of human NR1H3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor with ligand-dependent transcriptional activation activity. It interacts with retinoic acid receptor (RXR), converting RXR from a silent DNA-binding partner to an active ligand-binding subunit that mediates retinoid responses through LXRES target genes.
LXRES are DR4-type response elements composed of direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays a key role in cholesterol homeostasis, regulating cholesterol uptake via MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8, and functionally interacts with RORA in liver metabolism regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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