Thermo Fisher Scientific NR1H3 Monoclonal Antibody (OTI1F5), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor with ligand-dependent transcriptional activation activity. It interacts with retinoic acid receptor (RXR), converting RXR from a silent DNA-binding partner to an active ligand-binding subunit that mediates retinoid responses through LXRES target genes.
LXRES are DR4-type response elements composed of direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides.
NR1H3 plays a key role in cholesterol homeostasis, regulating cholesterol uptake via MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8, and functionally interacts with RORA in liver metabolism regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.