Thermo Fisher Scientific BIRC5 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Concentration: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein:

MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK KKEFEETAKK VRRAIEQLAA MD

Target Information

Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family.
IAPs are involved in multiple cellular functions such as signaling, division, and metabolism, and show differential expression in nearly all human cancers but not in most normal tissues.

Survivin contains a single BIR domain and lacks a C-terminal RING finger domain.
It is highly expressed during fetal development and in tumors, but low in adult tissues.
Expression peaks during the G2/M phase and associates with mitotic spindle microtubules.
Disruption of these interactions increases caspase-3 activity and apoptosis.
Survivin is also expressed in adult rat brain tissues following traumatic injury, suggesting a role in neural cell proliferation.

At least four transcript variants encode distinct isoforms, with three full-length forms identified.
Overexpression in cancer may bypass apoptotic checkpoints, promoting abnormal mitotic progression.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.