Thermo Fisher Scientific BIRC5 Polyclonal Antibody, MaxPab

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MGAPTLPPAW QPFLKDHRIS TFKNWPFLEG CACTPERMAE AGFIHCPTEN EPDLAQCFFC FKELEGWEPD DDPIEEHKKH SSGCAFLSVK KQFEELTLGE FLKLDRERAK NKIAKETNNK KKEFEETAKK VRRAIEQLAA MD

Target Information

Survivin (IAP4) is the smallest member of the Inhibitors of Apoptosis Protein (IAP) gene family.
IAPs are involved in multiple cell functions such as cell signaling, cell division, and metabolism, and exhibit differential expression in nearly all human cancers but not in most normal tissues.

• Survivin gene encodes proteins with a single BIR domain and lacks a C-terminal RING finger domain.
• Expression is high during fetal development and in most tumors, low in adult tissues.
• Survivin associates with microtubules of the mitotic spindle during mitosis, regulating apoptosis and caspase-3 activity.
• It is also expressed in brain tissues of adult rats following traumatic injury, potentially involved in neural cell proliferation.
• At least four transcript variants encoding distinct isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.