Thermo Fisher Scientific IL17RC Polyclonal Antibody
IL17RC 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태로, 장기 보관 시 -20°C 유지 권장.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IL17RC. Recombinant protein control fragment (Product #RP-90444). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642688 |
Product Specific Information
Immunogen sequence:
WDSDILCLPG DIVPAPGPVL APTHLQTELV LRCQKETDCD LCLRVAVHLA VHGHWEEPED EEKFGGAADS GVEEPRNASL QAQVVLSFQA YPTARCVLLE VQVPAALVQF GQSVGSVVYD CFEAALGSEV RIWSYTQPRY EKELNH
Sequence identity with orthologs:
- Mouse: 73%
- Rat: 76%
Target Information
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells and binds with high affinity only to IL-17A, this protein is expressed in nonhemopoietic tissues and binds both IL-17A and IL-17F with similar affinities.
The proinflammatory cytokines IL-17A and IL-17F have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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