Thermo Fisher Scientific Pericentrin Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Pericentrin. Recombinant protein control fragment (Product #RP-91791). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Pericentrin,uniProtId:O95613-1,ncbiNodeId:9606,antigenRange:2218-2346,antigenLength:3336,antigenImageFileName:PA5-54109_Pericentrin_O95613-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54109_Pericentrin_O95613-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645392

Product Specific Information

Immunogen sequence: MLDLSSWSSP EVLRKDWTLE PWPSLPVTPH SGALSLCSAD TSLGDRADTS LPQTQGPGLL CSPGVSAAAL ALQWAESPPA DDHHVQRTAV EKDVEDFITT SFDSQETLSS PPPGLEGKAD RSEKSDGSG

Highest antigen sequence identity to the following orthologs: Mouse - 58%, Rat - 58%.

Target Information

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.