Thermo Fisher Scientific FOXP3 Polyclonal Antibody, Biotin

Thermo Fisher Scientific FOXP3 Polyclonal Antibody, Biotin

Applications and Tested Dilutions

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acids 229–250 of Mouse Forkhead Box Protein 3 (FOXP3).
Sequence: AQCLLQREVVQSLEQQLELEKE
The peptide was post-synthetically modified for optimal antigenicity before coupling to a carrier protein.

Target Information

FOXP3 (Forkhead box protein 3) is a transcriptional regulator belonging to the forkhead/winged-helix family, essential for immune homeostasis.
It is highly expressed in CD25⁺ CD4⁺ regulatory T cells, weakly in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells.
FOXP3 functions as a master regulatory gene and serves as a specific marker for regulatory T cells.
Mutations in FOXP3 cause scurfy phenotype in mice and contribute to IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome) in humans.
Expression of FOXP3 in human breast and colon cancer cells is regulated by p53 in response to DNA damage.

Usage Notice

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.