Thermo Fisher Scientific FOXP3 Polyclonal Antibody, Biotin
FOXP3 단백질을 표적으로 하는 Thermo Fisher Scientific의 Biotin 결합 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합. 고순도 Affinity chromatography 정제 및 안정적인 액상 형태로 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- FOX3-BIOTIN
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific FOXP3 Polyclonal Antibody, Biotin
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Cat, Human, Mouse, Non-human primate, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Immunogen
Synthetic peptide corresponding to amino acids 229–250 of Mouse Forkhead Box Protein 3 (FOXP3).
Sequence: AQCLLQREVVQSLEQQLELEKE
The peptide was post-synthetically modified for optimal antigenicity before coupling to a carrier protein.
Target Information
FOXP3 (Forkhead box protein 3) is a transcriptional regulator belonging to the forkhead/winged-helix family, essential for immune homeostasis.
It is highly expressed in CD25⁺ CD4⁺ regulatory T cells, weakly in CD4⁺/CD25⁻ cells, and absent in CD4⁻/CD8⁺ T cells.
FOXP3 functions as a master regulatory gene and serves as a specific marker for regulatory T cells.
Mutations in FOXP3 cause scurfy phenotype in mice and contribute to IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome) in humans.
Expression of FOXP3 in human breast and colon cancer cells is regulated by p53 in response to DNA damage.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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