Thermo Fisher Scientific FOXP3 Polyclonal Antibody
FOXP3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종에서 반응하며 WB, IHC, ICC, ELISA 등 다중 응용 가능. 고순도 친화 크로마토그래피 정제, 안정적 액상 형태로 연구용 적합.
- 카탈로그번호
- FOX3-101AP
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific FOXP3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Cat, Human, Mouse, Non-human primate, Pig, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 229–250 of Mouse Forkhead Box Protein 3 (winged helix transcription factor 3 protein). The peptide was post-synthetically modified to achieve desired antigenicity before coupling to a carrier protein. Sequence: AQCLLQREVVQSLEQQLELEKE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25⁺ CD4⁺ regulatory T cells, a low level in CD4⁺/CD25⁻ cells, and is absent in CD4⁻/CD8⁺ T cells. FOXP3 may act as a master regulatory gene and a specific marker of regulatory T cells. Defects in the FOXP3 gene cause the scurfy phenotype in mice, and in humans are associated with IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants encoding different isoforms have been identified. In human breast and colon cancer cells, FOXP3 expression is regulated by p53 in response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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