Thermo Fisher Scientific Ataxin 3 Polyclonal Antibody
Ataxin 3 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 생쥐, 랫트 반응성. WB, IHC, ICC/IF, ELISA에 사용 가능. 핵 내부 위치 단백질 검출에 적합하며, 연구용으로만 사용.
- 카탈로그번호
- PA588538
- 판매단위
- pk
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Thermo Fisher Scientific Ataxin 3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–361 of human Ataxin-3 (ATXN3) (NP_004984.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.61 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804984 |
Product Specific Information
Immunogen sequence:
MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERMRMAE GGVTSEDYRT FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW FTVRKLGKQW FNLNSLLTGP ELISDTYLAL FLAQLQQEGY SIFVVKGDLP DCEADQLLQM IRVQQMHRPK LIGEELAQLK EQRVHKTDLE RVLEANDGSG MLDEDEEDLQ RALALSRQEI DMEDEEADLR RAIQLSMQGS SRNISQDMTQ TSGTNLTSEE LRKRREAYFE KQQQKQQQQQ QQQQQGDLSG QSSHPCERPA TSSGALGSDL GDAMSEEDML QAAVTMSLET VRNDLKTEGK K
Positive Samples: MCF7, SW480, Jurkat, A-549, DU145
Cellular Location: Nucleus matrix
Target Information
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and expansion of these repeats from the normal 13–36 to 68–79 causes the disease. There is a negative correlation between age of onset and CAG repeat number. Ataxin-3 interacts with transcription regulators (CBP, p300, PCAF), represses transcription, and acts as a histone-binding protein regulating transcription. MJD functions as a deubiquitinating enzyme.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명 예시: PA5-88538_Ataxin_3_P54252-2_Rabbit.svg, PA5-88538_Ataxin_3_P54252-2_Rabbit_PDP.jpeg)
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