Thermo Fisher Scientific KCNJ1 Polyclonal Antibody
Thermo Fisher Scientific의 KCNJ1 Polyclonal Antibody는 인간 KCNJ1 단백질을 인식하는 토끼 다클론 항체로, Western blot 및 IHC에 적합합니다. 합성 펩타이드 면역원 기반으로 제작되었으며, PBS 완충액에 동결건조 형태로 제공됩니다. 연구용 전용 제품입니다.
- 카탈로그번호
- OSK00012G-500UG
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the cytoplasmic domain of human KCNJ1 (ROMK1, Kir1.1) conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide shares 92% identity with rat and mouse sequences.
- Specificity: KCNJ1.
Target Information
Potassium channels are present in most mammalian cells and are involved in a wide range of physiological responses.
The KCNJ1 gene encodes an integral membrane inward-rectifier potassium channel activated by internal ATP, playing a key role in potassium homeostasis.
This protein favors potassium influx over efflux.
Mutations in KCNJ1 are associated with antenatal Bartter syndrome, characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure.
Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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