Thermo Fisher Scientific Lass4 Polyclonal Antibody
Lass4 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot과 IHC(Paraffin) 실험에 적합하며, 인간 및 생쥐 시료에 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보관됩니다.
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- PA549881
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal region of human LASS4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635334 |
Product Specific Information
This antibody detects endogenous levels of total Lass4 protein.
Target Information
The LASS (longevity assurance homolog) family members are highly conserved from yeast to mammals. Six members (LASS1–LASS6) have been characterized, all involved in sphingolipid synthesis. LASS4 is a 394-amino-acid, endoplasmic reticulum multi-pass membrane protein that increases levels of long ceramides such as C22:0 and C24:0. In CLN9-deficient cells, as observed in neuronal ceroid lipofuscinosis (NCL, Batten disease), LASS4 can elevate ceramide levels and partially correct growth and apoptosis defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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