Thermo Fisher Scientific E-cadherin Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• The immunizing peptide represents part of the extracellular domain.
• Tested in Peptide ELISA: antibody detection limit dilution 1:16,000.

Target Information

E-Cadherin (epithelial cadherin) is a classical cadherin belonging to the calcium-dependent adhesion protein superfamily. It is a cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. Mutations in this gene are associated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of E-cadherin function contributes to cancer progression by promoting proliferation, invasion, and metastasis. The ectodomain mediates bacterial adhesion to mammalian cells, while the cytoplasmic domain is required for internalization. E-cadherin is encoded by the CDH1 gene on chromosome 16 and plays a key role in maintaining tissue architecture and integrity. Reduced or lost expression of E-cadherin in carcinomas correlates with increased invasiveness and metastatic potential.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)