Thermo Fisher Scientific SCN11A Polyclonal Antibody
SCN11A 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunocytochemistry에 사용 가능. 인간 시료에 반응하며, 고순도 Affinity chromatography 정제. PBS/glycerol 완충액에 보관되며 -20°C에서 안정적 저장 가능.
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- PA5104156
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SCN11A (Accession Q9UI33), corresponding to amino acid residues E473–L523. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853484 |
Product Specific Information
Antibody detects endogenous levels of total SCN11A.
Target Information
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily share structural similarity, possessing two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous ENaC isoforms (alpha, beta, and gamma). ENaC in the kidney, lung, and colon is essential for trans-epithelial sodium and fluid balance. It also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, regulating blood pressure.
ENaC is thought to be regulated partly through association with the CFTR chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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