Thermo Fisher Scientific SCN11A Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total SCN11A.

Target Information

Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily share structural similarity, possessing two short intracellular termini, two membrane-spanning segments, and a large extracellular loop with a conserved cysteine-rich region.
There are three homologous ENaC isoforms (alpha, beta, and gamma). ENaC in the kidney, lung, and colon is essential for trans-epithelial sodium and fluid balance. It also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, regulating blood pressure.
ENaC is thought to be regulated partly through association with the CFTR chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddle’s syndrome), while loss-of-function mutations in alpha- or beta-ENaC cause pseudohypoaldosteronism (PHA-1).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.