Thermo Fisher Scientific APP Monoclonal Antibody (OTI4C3), TrueMAB
APP 단백질을 인식하는 OTI4C3 클론의 Mouse Monoclonal 항체. Western blot, ICC/IF, Flow Cytometry에 최적화. Lyophilized 형태로 제공되며, 재구성 시 1 mg/mL 농도 권장. Alzheimer’s disease 연구 및 APP 관련 단백질 발현 분석에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific APP Monoclonal Antibody (OTI4C3), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C3 |
| Immunogen | Full length human recombinant protein of human APP produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor mediating axonal transport of beta-secretase and presenilin 1.
APP is crucial for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein with multiple isoforms generated by alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases produces beta amyloid, the main component of senile plaques—a key hallmark of Alzheimer’s disease.
Abnormal APP regulation is also implicated in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.