Thermo Fisher Scientific DNMT3A Monoclonal Antibody (64B1446)
DNMT3A 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC, Flow cytometry 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트에 반응하며 Protein G로 정제된 액상 형태입니다. DNMT3A 관련 연구 및 메틸화 조절 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL | – |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | – |
| Immunocytochemistry (ICC/IF) | 1:10–1:500 | – |
| Flow Cytometry (Flow) | 1 µg per million cells | – |
| ChIP assay (ChIP) | Assay-Dependent | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Gerbil |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 64B1446 |
| Immunogen | Bacteria expressed recombinant mouse Dnmt3a |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537690 |
Product Specific Information
- In Western blot, detects a band at approximately 120 kDa (predicted molecular weight: 102 kDa).
- Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer (pH 6.0) for 10–20 min, followed by cooling at room temperature for 20 min.
- Suggested positive control: antigen standard for DNMT3A (transient overexpression lysate), transfected cell lysate (WB), HeLa cells (ICC).
Target Information
Methylation of DNA at cytosine residues plays an important role in the regulation of gene expression, genomic imprinting, and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with cancer development.
Three families of mammalian DNA methyltransferase genes have been identified: Dnmt1, Dnmt2, and Dnmt3.
- Dnmt1: Constitutively expressed in proliferating cells; its inactivation causes global demethylation and embryonic lethality.
- Dnmt2: Expressed at low levels in adult tissues; its inactivation does not affect DNA methylation.
- Dnmt3 family (Dnmt3a, Dnmt3b): Strongly expressed in embryonic stem (ES) cells, downregulated during differentiation, and low in adult somatic tissues.
- Mutations in Dnmt3b are associated with ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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