Thermo Fisher Scientific Mouse M-CSF Recombinant Protein

Applications

• Assay-dependent

Publications

• Miscellaneous PubMed (Misc): 2 publications available

Product Specifications

Product Specific Information

Recombinant mouse M-CSF is a disulfide-linked homodimer containing two 156 amino acid chains.
Reconstitute using sterile water at 0.1 mg/mL and centrifuge prior to opening vial.
Gently pipet solution down the sides of the vial. Do not vortex sample.
Store reconstituted material at -20ºC and add 0.1% BSA for additional stability.

Target Information

M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells.
It also induces VEGF secretion by macrophages, mediating mobilization of endothelial progenitor cells and neovascularization.
M-CSF exists in several bioactive isoforms differing in potency and stability.
The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or cleaved and modified in the secretory vesicle.
M-CSF is a disulfide-bonded homodimer processed into glycoprotein or proteoglycan isoforms modified by chondroitin sulfate addition.
Binding to its receptor c-Fms (CSF-1R or CD115) induces receptor dimerization, internalization, and degradation.
Functionally, M-CSF stimulates differentiation of hematopoietic stem cells into monocyte-macrophage populations in culture.
Human M-CSF shows activity on mouse cells, but mouse CSF shows no activity on human cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.