Thermo Fisher Scientific FPGT Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HeLaS3, Raji
• Predicted reactivity: Dog (84%), Pig (85%), Rabbit (82%), Rhesus Monkey (96%), Bovine (83%)
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

L-fucose is a key sugar in glycoproteins and other complex carbohydrates, involved in many functional roles such as cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-β-L-fucose.
There are two pathways for GDP-fucose biosynthesis:

• The major pathway converts GDP-α-D-mannose to GDP-β-L-fucose.
• The alternate salvage pathway, present in certain mammalian tissues (e.g., liver, kidney), reutilizes L-fucose from glycoprotein and glycolipid turnover.
  This pathway involves phosphorylation of L-fucose to β-L-fucose-1-phosphate, followed by condensation with GTP by fucose-1-phosphate guanylyltransferase to form GDP-β-L-fucose.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.