Thermo Fisher Scientific SH2D1A Polyclonal Antibody
SH2D1A 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 IHC(P)에서 사용 가능. 인간, 마우스, 랫트 반응성. 친화 크로마토그래피 정제, PBS/glycerol 완충액에 보관. 연구용 한정 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SH2D1A (Accession O60880), corresponding to amino acid residues T53–E103 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2851771 |
Product Specific Information
Antibody detects endogenous levels of total SH2D1A.
Target Information
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. The protein contains an SH2 domain and a short tail, and associates with the signaling lymphocyte-activation molecule (SLAM), acting as an inhibitor by blocking SHP-2 recruitment. It also binds to other related surface molecules on activated T, B, and NK cells, modulating signal transduction pathways. Mutations in this gene cause X-linked lymphoproliferative syndrome type 1 (Duncan disease), a rare immunodeficiency associated with Epstein–Barr virus susceptibility, severe mononucleosis, and malignant lymphoma. Multiple transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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