Thermo Fisher Scientific Podoplanin Monoclonal Antibody (NZ-1.2)
인간 Podoplanin을 인식하는 Rat 모노클로날 항체로 다양한 조직 염색 및 세포 분석에 사용 가능. Western blot, IHC, ICC, Flow cytometry에 최적화된 농도 제공. 비결합형 액상 형태로 안정적이며 장기 보관 가능.
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Thermo Fisher Scientific Podoplanin Monoclonal Antibody (NZ-1.2)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 3–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 0.5–1 µg/mL |
| Immunohistochemistry (Frozen) (IHC-F) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 0.2–1 µg per million cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2a, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NZ-1.2 |
| Immunogen | Synthetic peptide corresponding to amino acids 38–70 (EGGVAMPGAEDDVV) from the platelet-aggregation-stimulating (PLAG) domain of human podoplanin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537784 |
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of 40–43 kDa. It is expressed in various tumors and normal cells, particularly lymphatic epithelial cells and follicular dendritic cells. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells.
As a regulator of lymphatic endothelium, podoplanin likely contributes to maintaining the unique shape of podocytes. It serves as a ligand for CLEC-2, and its expression correlates with tumor invasiveness and metastatic potential. Podoplanin is directly involved in cell migration, metastasis formation, and tumor cell invasion.
Podoplanin expression can be induced through Src activation of Cas and has been detected on Th17 cells. Studies show its presence on a distinct population of CD4+ cells from human PBMC. Dysfunction of podoplanin has been linked to diseases such as lymphangioma and subglottic neoplasm. It is also proposed as a marker for lung injury due to its physiological role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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