Thermo Fisher Scientific RBM8A Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.25 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 4–8 µg/mL

Product Specifications

Product Specific Information

• Peptide sequence: LHEAGGEDFA MDEDGDESIH KLKEKAKKRK GRGFGSEEGS RARMREDYDS
• Sequence homology:
  • Cow: 100%
  • Dog: 100%
  • Horse: 100%
  • Human: 100%
  • Mouse: 100%
  • Pig: 82%
  • Rabbit: 82%
  • Rat: 100%
  • Zebrafish: 100%

Target Information

This gene encodes a protein with a conserved RNA-binding motif. The protein is found predominantly in the nucleus, although it is also present in the cytoplasm. It is preferentially associated with mRNAs produced by splicing, including both nuclear mRNAs and newly exported cytoplasmic mRNAs. It is thought that the protein remains associated with spliced mRNAs as a tag to indicate where introns had been present, thus coupling pre- and post-mRNA splicing events. Previously, it was thought that two genes encode this protein, RBM8A and RBM8B; it is now considered that the RBM8B locus is a pseudogene. Two alternative start codons result in two forms of the protein, and this gene also uses multiple polyadenylation sites.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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