Thermo Fisher Scientific TIAF1 Polyclonal Antibody
TIAF1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 항체. 인간 및 생쥐 반응성. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the amino terminus of human TIAF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551890 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-34538 can be used with blocking peptide PEP-1581
Target Information
TIAF-1 (TGFB1-induced anti-apoptotic factor 1), also known as MYO18A, is a TGFB1-induced anti-apoptotic factor that inhibits the cytotoxic effects of TNF-alpha, TRADD, and FADD.
It localizes to the nucleus and is significantly up-regulated in activated helper T lymphocytes (TH2) during chronic kidney and liver allograft rejection.
Suppression of TIAF1 expression by siRNA prevents UV irradiation-mediated p53 phosphorylation and nuclear translocation.
TIAF1 is essential in p53- and WOX1-mediated cell death and plays a role in aggregation-dependent control of tumor progression, metastasis, and regulation of cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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