Thermo Fisher Scientific TIM-4 Monoclonal Antibody (Kat5-18), FITC

Applications and Tested Dilution

Product Specifications

Product Specific Information

The monoclonal antibody Kat5-18 blocks the engulfment of apoptotic cells by thymic macrophages.

Target Information

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors involved in the regulation of T helper (Th)-1 and Th-2 cell-mediated immunity.
TIM-4, preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production.
Unlike other TIM family members, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain.
The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and, due to its connection to TIM-1-triggered Th2 responsiveness, may be considered a candidate disease/predisposition gene for asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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