Thermo Fisher Scientific TIM-4 Monoclonal Antibody (Kat5-18)

Thermo Fisher Scientific TIM-4 Monoclonal Antibody (Kat5-18)

Applications and Tested Dilution

Product Specifications

Additional Formats

• FITC Conjugate
• Request custom conjugation

Product Specific Information

The monoclonal antibody Kat5-18 blocks the engulfment of apoptotic cells by thymic macrophages.

Target Information

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors involved in the regulation of T helper (Th)-1 and Th-2 cell-mediated immunity.
TIM-4, preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, leading to T-cell expansion and cytokine production.
Unlike other TIM family members, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain.
The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and, with its connection to TIM-1-triggered Th2 responsiveness, may be considered a candidate disease/predisposition gene for asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: MA5-49108_TIM-4_TIMD4_Q6U7R4-1_Armenian_hamster.svg / MA5-49108_TIM-4_TIMD4_Q6U7R4-1_Armenian_hamster_PDP.jpeg)