Thermo Fisher Scientific ZEB2 Monoclonal Antibody (OTI15G8), TrueMAB
인간 ZEB2 단백질을 인식하는 Mouse IgG1 단클론 항체로 Western blot 및 IHC(P) 검증 완료. 비결합형 액상 형태로 1 mg/mL 농도 제공. 세포 이동 및 암 관련 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI15G8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–350 of human ZEB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is located in the nucleus and functions as a DNA-binding transcriptional repressor interacting with activated SMADs. Similar to ZEB1, ZEB2 inhibits transcription of the E-cadherin gene and induces epithelial-mesenchymal transition (EMT), a key process in cell migration during embryonic development and wound healing. ZEB2 also protects cells from DNA damage-induced apoptosis, implicating its role in tumor progression. It is frequently observed in the cytoplasm of various cancer tissues, suggesting regulated localization in normal and tumor cells. Mutations in ZEB2 are associated with Hirschsprung disease and Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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