Thermo Fisher Scientific c-Abl Polyclonal Antibody
Rabbit 폴리클로날 항체로 인간 c-Abl 단백질을 인식합니다. Western blot과 IHC(P)에서 검증되었습니다. 세포 분화, 세포 주기, 스트레스 반응 연구에 적합합니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic non-phosphopeptide derived from human c-Abl around the phosphorylation site of Tyr412 (D-T-YP-T-A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2556239 |
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response.
c-Abl activity is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene.
Its DNA-binding activity is regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle.
In chronic myelogenous leukemia and some acute lymphoblastic leukemias, a (9;22) chromosomal translocation produces the Philadelphia chromosome, fusing c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22.
The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV).
c-Abl may regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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