Thermo Fisher Scientific Phospho-TEK (Tyr1108) Polyclonal Antibody
Phospho-TEK (Tyr1108) 폴리클로날 항체로 인간 및 생쥐 시료에 반응. Western blot 및 Immunocytochemistry에 적합. 항원 친화 크로마토그래피로 정제된 고순도 항체. 혈관 발달 및 TEK 신호 연구용으로 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human TIE2 around the phosphorylation site of Tyr1108 (T-L-YP-E-K) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco's PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554940 |
Target Information
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells. TEK signaling is critical for endothelial cell–smooth muscle cell communication in venous morphogenesis, and defects in TEK are associated with inherited venous malformations.
The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway involved in embryonic vascular development.
Immunoblotting showed that TIE2 expression increases in response to thyroid-stimulating hormone and agents that elevate intracellular cAMP.
Hematopoietic stem cells (HSCs) expressing TIE2 are quiescent and antiapoptotic, forming a side population that adheres to osteoblasts in the bone marrow niche.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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