Thermo Fisher Scientific PYGL Polyclonal Antibody
Thermo Fisher Scientific의 PYGL Polyclonal Antibody는 Human, Mouse, Rat 시료에 반응하며 IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Rabbit IgG 기반의 비결합 항체로, 고순도 Protein A 정제 방식으로 제조되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human PYGL (amino acids 451–550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a homodimeric protein that catalyzes the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. The protein switches from inactive phosphorylase B to active phosphorylase A via phosphorylation at serine residue 15. Its activity is regulated by allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes encoding distinct isozymes primarily expressed in liver, brain, and muscle. The liver isozyme supports systemic glucose demands, while brain and muscle isozymes serve local needs. Mutations in the liver glycogen phosphorylase gene cause glycogen storage disease type VI (Hers disease), characterized by moderate hypoglycemia, mild ketosis, growth retardation, and hepatomegaly. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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