Thermo Fisher Scientific PIK3C2A Monoclonal Antibody (OTI3D9)
PIK3C2A 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, WB와 IHC(P) 실험에 적합합니다. 인간 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. Affinity Chromatography로 정제되어 안정적이며, 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 230–560 of PIK3C2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725025 |
Target Information
Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though less studied than Class I PI3 kinases, Class II enzymes are linked to diverse receptor-mediated cellular processes such as insulin signaling, neuronal survival, and growth factor signaling.
PI3-kinases are involved in pathways regulating cell proliferation, oncogenic transformation, survival, migration, and intracellular trafficking.
PIK3C2A contains a lipid kinase catalytic domain and a C-terminal C2 domain, characteristic of Class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs mediating membrane translocation and protein-protein interactions.
Its PI3-kinase activity is not sensitive to nanomolar levels of wortmanin and can be activated by insulin, potentially participating in integrin-dependent signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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